Vitamin B12
share as inverse relationship with homocysteine, and its deficiency results in
hyperhomocysteinemia . Homocysteine is produced due to demethylation of
methionine. This metabolism depends on vitamin cofactors such as vitamins B6
,B9,B12 . hyperhomocysteinemia is generally caused due to decreased intake or
absorption of any of these B-complex vitamins. As per Aubard(2000),
hyperhomocysteinemea is associated with various adverse pregnancy outcomes such
as pre-eclampsia, abruption placenta, thromboembolic events, syndromes of
repeated miscarriage, NTDs, fetal death-in-utero and IUGR.
